Technology
 
CritiView monitors are based on proprietary, patented technology for measuring key parameters of tissue viability continuously, simultaneously and in real-time with a single probe. CritiView simultaneously measures mitochondrial NADH, blood oxygenation, microcirculatory blood flow and tissue reflectance.

Tissue viability depends on the balance between the oxygen supply to, and the oxygen demand by the body's organs. Microcirculatory blood flow and volume as well as local blood oxygenation,
represent the regulatory process of O2 supply and delivery to the tissue.
An intracellular biological factor - mitochondrial NADH redox state - serves as marker of the energy generation process and oxygen balance in the cell. Imbalances in the energy regime will be translated into changes of the NADH levels. The patented optical technology (CritiView) is based on continuous, real-time concurrent monitoring of four critical parameters from the same tissue volume by one single probe. These parameters: NADH redox state, microcirculatory blood flow, microcirculatory blood oxygenation and tissue reflectance are highly correlated to tissue viability.
The CritiView illuminates tissue by low power light and detects light that is subsequently emitted
therefrom.The light is guided to the tissue by a bundle of flexible optical fibers and emitted from the tissue both by reflection and fluorescence. The emitted light is collected by the same bundle of optical fibers that are combined in a proprietary probe. The detected optical signals are converted into electronic signals, which are in turn processed by the central-processing unit. The light emitted from the tissue is comprised of four separate components:

1.  A Doppler shifted reflected light, at the excitation wavelength, indicative of microcirculatory blood flow (TBF).
 
2.  Total back scattered or reflected light, correlated to blood volume at the observed tissue block.
 
3.  Fluorescence light, emitted by intracellular NADH, indicative of the cellular mitochondrial function and of the tissue's metabolic state. This constitutes a novel marker for the energetic state of the tissue.
 
4.  Reflected light (at 2 specific wavelength) affected by the level of hemoglobin oxygenation at the microcirculation level.



In-Vivo Tissue Spectroscopy





 

  ©2008 All Rights Reserved to CritiSense